If you'll do a 75g water change, nitrates will measure 40. Do another 75g a few days later, nitrates will measure 20. Do another 75g two days later, they will measure 10. Every 50% water change will cut them in half.
And once they are down, it will be easier to keep them down.
The question is, how did the number get so high? Is this an ongoing situation or did they creep up and you are now wanting a solution? Do you have anything in your system that generates nitrate (bioballs, biobale, sponges, biowheels, filter socks)?