If you are using the canister filter first before going to the skimmer, you'll be using up filter media much faster than if you had the skimmer first in the loop. The skimmer will take out the bulk of the garbage and most nutirents, then the canister filter will polish the water from there with carbon or whatever your chosen chemical media would be. Don't use the canister for mechanical filtration (floss, bioballs, ceramic rings, rubble, sponges...) it'll frustrate you with how often it'll need to be opened and cleaned and can cause buildup issues too.