[It's going to depend on location, the building and weight distribution like mentioned above.
I live on the second floor in a duplex built in the early 40's. I had an Architect budding of mine come over and inspect the joint. Due to the building techniques of that time and the second floor construction, the spanse of the floor between walls, etc.. I'm good with my 90g, 110lbs of rock and a 29g sump, and a DSB. Was definately holding my breath filling it up. I would not have gone larger.
I did place the tank on an outside wall and the floor joists are perpendiculiar to the tank/wall. I tried to situate the tank on as many supports as I could. There is also a wood floor, padding and carpet under there as well.
Do some searches on reefs.org. I know I had an in depth conversation with several folks over there about a year ago. My name is "Modo" over there as well.]