If it dies, it dissolves. Which is why it is important to do the water change to get that stuff out of the water. Your skimmer will go crazy when you restart it after the 48 hour period, so be ready for that. You should make more saltwater to replace what is being lost.
Last time I dosed, my skimmer was on its lowest setting and still dumped out 9.5g of water in 3 hours.